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Chloroquine - Wikipedia
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Blastocystosis : metronidazole. Sodium aurothiomalate Sodium aurothiosulfate Auranofin Aurothioglucose Aurotioprol. Glutamate metabolism and transport modulators. Authority control NDL : However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Specifically, anti-malarial medications have shown to improve muscle and joint pain, skin rashes, pericarditis inflammation of the lining of the heart , pleuritis inflammation of the lining of the lung , and other lupus symptoms such as fatigue and fever.
Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Studies have shown lupus patients on anti-malarials actually live longer than those who are not, and these medications are usually prescribed when someone is first diagnosed with the disease.
However, anti-malarials are not a sufficient treatment for more severe lupus symptoms such as kidney disease and nervous system or blood vessel involvement. When lupus spreads to these organs, immunosuppressive medications are usually added to help minimize irreversible injury. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used.
Quinacrine Atabrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the patient does not respond to Plaquenil alone. Quinacrine tablets are no longer manufactured and can only be obtained through a compounding pharmacist. Your doctor will advise you on how to obtain quinacrine if this becomes your advised method of treatment.
Anti-malarial medications help to control lupus in several ways by modulating the immune system without predisposing you to infection.
Hydroxychloroquine and Chloroquine
Anti-malarials can protect against UV light and sometimes even improve skin lesions that do not respond to treatment with topical therapy ointments. Anti-malarial medications may prevent activation of plasmacytoid dendritic cells, a component of the immune system that is responsible for making interferon. Yes, anti-malarials can be taken with other lupus medications, including corticosteroids e.
Anti-malarial drugs may be given in combination with prednisone to reduce the amount of steroid needed to control lupus symptoms and thus to alleviate some of the side effects of the steroid. In addition, since it usually takes about months for your anti-malarial medications to fully take effect, you may be given a steroid medication to act as a bridging medication and alleviate your symptoms during this interim. Anti-malarials are safe to use during pregnancy, but you should speak to your doctor if you are pregnant or may become pregnant to decide the course of treatment that will be best for you.
No fetal abnormalities are known to have occurred from taking hydroxychloroquine, and physicians at several major universities have used anti-malarial drugs for years to treat pregnant women with lupus without negative side effects on the fetus. Damage to the retina, the light sensitive portion of the inner eye, can occur with long-term use of Plaquenil or chloroquine Aralen. With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5, people who take the drug for five years or more.
For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus.
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- Comparison of hydroxychloroquine and chloroquine use and the development of retinal toxicity.;
Follow-up exams every 6 months or, annually at the very least are also advised. You can also monitor yourself between visits with a special grid called an Amsler grid, which can be obtained through your ophthalmologist. Unfortunately, retinal damage caused by Aralen may be irreversible, but this medication is rarely prescribed anymore for lupus. Do not smoke while taking anti-malarial medications, since smoking actually reduces the benefits of these drugs.
Who uses hydroxychloroquine?
In fact, people with lupus should not smoke at all due to their increased risk of cardiovascular disease. You should always take your anti-malarial medications with food to prevent stomach upset. If a stomachache does occur, it is usually temporary. However, if you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead.
While these medications contain the same active ingredient, the preparation of generic hydroxychloroquine can sometimes cause stomach irritation.