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It then migrates to the liver, where it matures into schizonts and multiplies. The next stage of the plasmodium life cycle called merozoite is released into the blood, infects red blood cells and transforms into the trophozoite that causes destruction of red blood cells. Some merozoites transform into gametocytes and are taken up by a mosquito when feeding on blood to begin a new cycle.

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Symptoms of malaria, including fever, shivering, headache, vomiting, muscle pain, and joint pain, usually appear 10 to 15 days after the mosquito bite. However, if left untreated, malaria can quickly become life-threatening, causing anaemia and brain damage and disrupting the blood supply to vital organs. Plaquenil tablets mg contain the antimalarial hydroxychloroquine, which is active against the trophozoite stage of the plasmodium parasitic life cycle that infects red blood cells and causes their destruction. Haemoglobin, the oxygen carrying protein in blood, is released when the red blood cells are destroyed.

The plasmodium parasite digests haemoglobin forming the compound haem which is toxic to cells. Haem is converted by a parasitic enzyme to the insoluble crystalline form haemozoin that is not toxic to plasmodium. If the parasite survives in the blood due to inadequate anti-malarial treatment or lies dormant in the liver this can lead to recurrent malaria. Hydroxychloroquine in Plaquenil tablets mg are highly active against the erythrocytic forms of P.

However, they are not effective against the gametocytes of P. Plaquenil tablets mg contain hydroxychloroquine, the antimalarial and disease-modifying antirheumatic drug DMARD used to treat chronic rheumatic diseases that have an autoimmune basis when the immune system is directed against self , such as acute and chronic arthritis and mild systemic lupus erythematosus SLE and discoid lupus erythematosus DLE. These conditions are characterised by inflammation and destruction of tissues.

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Rheumatoid arthritis is a chronic inflammation of the joints causing swelling, stiffness and pain and is due to inflammation of the synovial membrane, which forms a protective capsule around the joint. Systemic lupus erythematosus is characterised by the formation of autoantibodies that become deposited in various parts of the body and causes damage to the tissues and organs, including the heart, lungs, skin, joints, blood vessels, liver kidney and nervous system.

Discoid lupus erythematosus is a form of lupus erythematosus that characterised by skin lesions caused deposition of autoantibodies and chronic inflammation of the skin but is not as serious as the systemic form.

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Antimalarials like hydroxychloroquine in Plaquenil tablets mg have been found to have various immunomodulatory effects ability to influence and modify the immune system as well as antiinflamatory effects, and are classified as disease-modifying antirheumatic drug DMARD. There are several mechanisms by which hydroxychloroquine is thought to exert its beneficial effects.

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These combined actions of hydroxychloroquine in Plaquenil tablets mg help slow down the progression of chronic rheumatic diseases, such as acute and chronic arthritis and mild SLE and DLE. The most commonly reported side effects when taking Plaquenil tablets mg include: abdominal pain, nausea, diarrhoea, vomiting, loss of appetite, headache, skin rash, pruritus itching , vertigo, tinnitus, nerve deafness, nervousness, dizziness hair loss, blurring of vision. Several medications interact with Plaquenil tablets mg and should either not be taken while you are taking Plaquenil or only after discussion and instruction from your doctor:.

You should take your Plaquenil tablets mg with a glass and with food of water. For rheumatoid arthritis, SLE and DLE you should take your Plaquenil tablets mg times daily for several weeks as recommended by your doctor. For prevention of malaria you should take your Plaquenil tablets mg once a week on the same day each week. For the treatment of malaria you should take your Plaquenil tablets mg twice a day on the first day with hours between doses and then on the next 2 consecutive days.

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